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Toll-like Receptors, LPS, and Dental Monomers

URN to cite this document:
urn:nbn:de:bvb:355-epub-341810
Schmalz, G. ; Krifka, Stephanie ; Schweikl, Helmut
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Date of publication of this fulltext: 09 Aug 2016 10:45


Abstract

Unreacted monomers released from dental resin-based composites at non-cytotoxic concentrations cause a depletion of glutathione and an increase of reactive oxygen species (ROS), leading to, e.g., DNA damage and apoptosis. ROS-sensitive MAP-kinases are activated by HEMA and TEGDMA. MAP-kinases are also involved in the bacteria-triggered cell responses of the innate immune system, e.g., after ...

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