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Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series

Dove, Stefan and Buschauer, Armin (1998) Imidazolylpropylguanidines as histamine H_2 receptor agonists: 3D-QSAR of a large series. Pharm. Acta Helv. 73 (3), pp. 145-155.

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Imidazolylpropylguanidines are potent histamine H2 receptor agonists and act as inotropic vasodilators. A large series of 141 derivatives was tested in the isolated guinea pig atrium and submitted to CoMFA. Since all compounds are full agonists, pD2 values reflect H2 receptor binding. Hydrophobicity was considered as Σf of the variable structural moiety, calculated by the Leo–Hansch method. ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
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Keywords:3D-QSAR; CoMFA; Histamine H2 receptor agonists; Cardiotonics
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:3420
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