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UVA irradiation of fatty acids and their oxidized products substantially increases their ability to generate singlet oxygen

URN to cite this document:
urn:nbn:de:bvb:355-epub-342247
Regensburger, Johannes ; Maisch, Tim ; Knak, Alena ; Gollmer, Anita ; Felgenträger, Ariane ; Lehner, Karin ; Bäumler, Wolfgang
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Date of publication of this fulltext: 03 Aug 2016 08:15


Abstract

UVA radiation plays an important role for adverse reactions in human tissue. UVA penetrates epidermis and dermis of skin being absorbed by various biomolecules, especially endogenous photosensitizers. This may generate deleterious singlet oxygen (1O2) that oxidizes fatty acids in cell membranes, lipoproteins, and other lipid-containing structures such as the epidermal barrier. Indications exist ...

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