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Actin nucleation: bacteria get in-Spired

Quinlan, M. E. and Kerkhoff, Eugen (2008) Actin nucleation: bacteria get in-Spired. Nat. Cell Biol. 10 (1), pp. 13-15.

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Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family. The discovery of Spir-like proteins in bacteria indicates that pathogens have adopted this mechanism to manipulate the host actin cytoskeleton.

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Item type:Article
Date:January 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
18172428PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34324
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