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Actin nucleation: bacteria get in-Spired

Quinlan, M. E. ; Kerkhoff, Eugen



Abstract

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family. The discovery of Spir-like proteins in bacteria indicates that pathogens have adopted this mechanism to manipulate the host actin cytoskeleton.


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