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The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways

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Schmelzer, K. R. ; Wheelock, A. M. ; Dettmer, Katja ; Morin, D. ; Hammock, B. D.
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Date of publication of this fulltext: 18 Aug 2016 08:20


Ambient air is polluted with a mixture of pulmonary toxicants. Previous studies indicate that prior exposure to atmospheric oxidant pollutants such as ozone may significantly alter the response to other pollutants, such as 1-nitronaphthalene (1-NN). 1-NN, a component of the particulate exhaust from diesel engines, has been found at low concentrations in ambient air. Using a metabolomic approach, ...


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