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Conservation of the RB1 gene in human and primates

Sivakumaran, T. A. ; Shen, P. ; Wall, D. P. ; Do, B. H. ; Kucheria, K. ; Oefner, Peter J.


Mutations in the RB1 gene are associated with retinoblastoma, which has served as an important model for understanding hereditary predisposition to cancer. Despite the great scrutiny that RB1 has enjoyed as the prototypical tumor suppressor gene, it has never been the object of a comprehensive survey of sequence variation in diverse human populations and primates. Therefore, we analyzed the ...


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