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Conservation of the RB1 gene in human and primates

Sivakumaran, T. A., Shen, P., Wall, D. P., Do, B. H., Kucheria, K. and Oefner, Peter J. (2005) Conservation of the RB1 gene in human and primates. Human Mutation 25 (4), pp. 396-409.

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Other URL: http://onlinelibrary.wiley.com/doi/10.1002/humu.20154/epdf


Mutations in the RB1 gene are associated with retinoblastoma, which has served as an important model for understanding hereditary predisposition to cancer. Despite the great scrutiny that RB1 has enjoyed as the prototypical tumor suppressor gene, it has never been the object of a comprehensive survey of sequence variation in diverse human populations and primates. Therefore, we analyzed the ...


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Item type:Article
Date:17 March 2005
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
15776430PubMed ID
Keywords:retinoblastoma; RB1; SNP; haplotype; nucleotide diversity; HKA test; maximum likelihood ratio
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:34347
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