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Unusual beta-sheet periodicity in small cyclic peptides

Gibbs, A. C., Kondejewski, L. H., Gronwald, Wolfram, Nip, A. M., Hodges, R. S., Sykes, B. D. and Wishart, D. S. (1998) Unusual beta-sheet periodicity in small cyclic peptides. Nature Structural & Molecular Biology (formerly: Nature Structural Biology) 5 (4), pp. 284-288.

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Abstract

Cyclic peptide homologs of gramicidin S containing 6, 8, 10, 12, 14 and 16 residues were synthesized and characterized using circular dichroism (CD) and 1H NMR spectroscopy. Based on the three-dimensional structures generated from these data we have found strong evidence of a periodic sequence-length dependence on beta-sheet content. In particular, peptides of length 6, 10 and 14 residues exhibit ...

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Item type:Article
Date:April 1998
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
9546219PubMed ID
10.1038/nsb0498-284DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:34357
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