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Unusual beta-sheet periodicity in small cyclic peptides

Gibbs, A. C. ; Kondejewski, L. H. ; Gronwald, Wolfram ; Nip, A. M. ; Hodges, R. S. ; Sykes, B. D. ; Wishart, D. S.


Cyclic peptide homologs of gramicidin S containing 6, 8, 10, 12, 14 and 16 residues were synthesized and characterized using circular dichroism (CD) and 1H NMR spectroscopy. Based on the three-dimensional structures generated from these data we have found strong evidence of a periodic sequence-length dependence on beta-sheet content. In particular, peptides of length 6, 10 and 14 residues exhibit ...


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