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The structure of human parathyroid hormone from a study of fragments in solution using 1H NMR spectroscopy and its biological implications

Wray, V. ; Federau, T. ; Gronwald, Wolfram ; Mayer, H. ; Schomburg, D. ; Tegge, W. ; Wingender, E.


In order to gain insight into the structure of human parathyroid hormone (hPTH), four fragments [hPTH(1-34), hPTH(18-48), hPTH(28-48), and hPTH(53-84)], which cover all regions of the intact hormone, have been investigated by CD and NMR spectroscopy in combination with distance geometry, and restrained molecular dynamics and energy minimization calculations, under a variety of solution ...


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