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Pathway activation patterns in diffuse large B-cell lymphomas

Bentink, Stefan ; Wessendorf, S. ; Schwaenen, C. ; Rosolowski, M. ; Klapper, W. ; Rosenwald, A. ; Ott, G. ; Banham, A. H. ; Berger, H. ; Feller, A. C. ; Hansmann, M. L. ; Hasenclever, D. ; Hummel, M. ; Lenze, D. ; Möller, P. ; Stuerzenhofecker, B. ; Loeffler, M. ; Truemper, L. ; Stein, H. ; Siebert, R. ; Spang, Rainer



Abstract

Deregulation of cell signaling pathways controlling cell growth and cell survival is a common feature of all cancers. Although a core repertoire of oncogenic mechanisms is widely conserved between various malignancies, the constellation of pathway activities can vary even in patients with the same malignant disease. Modern molecularly targeted cancer drugs intervene in cell signaling compensating ...

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