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CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells

Hirsch, Burkhard ; Hummel, M. ; Bentink, Stefan ; Fouladi, F. ; Spang, Rainer ; Zollinger, R. ; Stein, H. ; Durkop, H.



Abstract

High CD30 expression in classical Hodgkin's lymphoma and anaplastic large cell lymphoma (ALCL) suggests an important pathogenic role of this cytokine receptor. To test this hypothesis, we investigated CD30 signaling in Hodgkin's and ALCL cell lines by different approaches: 1) CD30 stimulation, 2) CD30 down-regulation, and 3) a combination of both. The effects were determined at the RNA ...

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