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CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells

Hirsch, Burkhard, Hummel, M., Bentink, Stefan, Fouladi, F., Spang, Rainer, Zollinger, R., Stein, H. and Durkop, H. (2008) CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. The American Journal of Pathology 172 (2), pp. 510-520.

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Abstract

High CD30 expression in classical Hodgkin's lymphoma and anaplastic large cell lymphoma (ALCL) suggests an important pathogenic role of this cytokine receptor. To test this hypothesis, we investigated CD30 signaling in Hodgkin's and ALCL cell lines by different approaches: 1) CD30 stimulation, 2) CD30 down-regulation, and 3) a combination of both. The effects were determined at the RNA ...

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Item type:Article
Date:February 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
18187570PubMed ID
10.2353/ajpath.2008.070858DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34373
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