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Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast

Sinha, H., David, L., Pascon, R. C., Clauder-Münster, S., Krishnakumar, S., Nguyen, M., Shi, G., Dean, J., Davis, R. W., Oefner, Peter J., McCusker, J. H. and Steinmetz, L. M. (2008) Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics 180 (3), pp. 1661-1670.

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Abstract

Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross mapping strategy that genetically eliminated the effect of a previously ...

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Item type:Article
Date:November 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
18780730PubMed ID
10.1534/genetics.108.092932DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34379
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