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Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia

Kirschner-Schwabe, R., Lottaz, Claudio, Todling, J., Rhein, P., Karawajew, L., Eckert, C., von Stackelberg, A., Ungethum, U., Kostka, Dennis, Kulozik, A. E., Ludwig, W. D., Henze, G., Spang, Rainer, Hagemeier, C. and Seeger, K. (2006) Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia. Clinical Cancer Research 12 (15), pp. 4553-4561.

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Other URL: http://clincancerres.aacrjournals.org/content/12/15/4553.full-text.pdf


Abstract

PURPOSE: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall cure rates of 40% remain unsatisfactory and survival rates are particularly poor in certain subgroups. The probability of long-term survival after relapse is predicted from well-established prognostic factors (i.e., time and site ...

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Item type:Article
Date:1 August 2006
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
16899601PubMed ID
10.1158/1078-0432.CCR-06-0235UNSPECIFIED
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:34389
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