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Early diagnostic marker panel determination for microarray based clinical studies

Jaeger, J., Weichenhan, D., Ivandic, B. and Spang, Rainer (2005) Early diagnostic marker panel determination for microarray based clinical studies. Statistical Applications in Genetics and Molecular Biology 4 (1), article 9.

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Other URL: http://www.degruyter.com/view/j/sagmb.2005.4.issue-1/sagmb.2005.4.1.1109/sagmb.2005.4.1.1109.xml


Abstract

We present a novel, cost efficient two-phase design for predictive clinical gene expression studies: early marker panel determination (EMPD). In Phase-1, genome-wide microarrays are used only for a small number of individual patient samples. From this Phase-1 data a panel of marker genes is derived. In Phase-2, the expression values of these marker panel genes are measured for a large group of ...

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Item type:Article
Date:26 April 2005
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
16646862PubMed ID
10.2202/1544-6115.1109DOI
Keywords:medical diagnostics; diagnostic chip design; microarray; gene expression; marker genes
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:34391
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