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Early diagnostic marker panel determination for microarray based clinical studies

Jaeger, J. ; Weichenhan, D. ; Ivandic, B. ; Spang, Rainer


We present a novel, cost efficient two-phase design for predictive clinical gene expression studies: early marker panel determination (EMPD). In Phase-1, genome-wide microarrays are used only for a small number of individual patient samples. From this Phase-1 data a panel of marker genes is derived. In Phase-2, the expression values of these marker panel genes are measured for a large group of ...


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