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Differential myocardial gene expression in the development and rescue of murine heart failure

Blaxall, B. C. ; Spang, Rainer ; Rockman, H. A. ; Koch, W. J.


Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be "rescued" or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARKct). To uncover genomic changes associated with cardiomyopathy and/or its ...


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