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A novel approach to remote homology detection: jumping alignments

Spang, Rainer, Rehmsmeier, M. and Stoye, J. (2002) A novel approach to remote homology detection: jumping alignments. Journal of Computational Biology 9 (5), pp. 747-760.

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Other URL: http://online.liebertpub.com/doi/pdf/10.1089/106652702761034172


We describe a new algorithm for protein classification and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alignment in a well-balanced manner. This is in contrast to established methods such as profiles and profile hidden Markov models which focus on vertical information as they model the columns of the alignment independently ...


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Item type:Article
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
12487762PubMed ID
Keywords:sequence analysis, protein classification, homology detection, jumping alignments
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:34402
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