Go to content
UR Home

TNFR2 maintains adequate IL-12 production by dendritic cells in inflammatory responses by regulating endogenous TNF levels

Martin, E. M., Remke, A., Pfeifer, E., Polz, Johannes, Pietryga-Krieger, A., Steffens-Weber, D., Freudenberg, M., Mostböck, Sven and Männel, Daniela N. (2013) TNFR2 maintains adequate IL-12 production by dendritic cells in inflammatory responses by regulating endogenous TNF levels. Innate Immunity 20, pp. 712-720.

[img]
Preview
License: Allianz- bzw. Nationallizenz
PDF - Published Version
Download (274kB)
Date of publication of this fulltext: 26 Aug 2016 05:37

at publisher (via DOI)


Abstract

Sepsis-induced immune reactions are reduced in TNF receptor 2 (TNFR2)-deficient mice as previously shown. In order to elucidate the underlying mechanisms, the functional integrity of myeloid cells of TNFR2-deficient mice was analyzed and compared to wild type (WT) mice. The capacity of dendritic cells to produce IL-12 was strongly impaired in TNF-deficient mice, mirroring impaired production of ...

plus


Export bibliographical data



Item type:Article
Date:2013
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
10.1177/1753425913506949DOI
Keywords:Tolerance, tumor necrosis factor, inflammation, immune suppression
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34468
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons