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TNFR2 maintains adequate IL-12 production by dendritic cells in inflammatory responses by regulating endogenous TNF levels

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Martin, E. M. ; Remke, A. ; Pfeifer, E. ; Polz, Johannes ; Pietryga-Krieger, A. ; Steffens-Weber, D. ; Freudenberg, M. ; Mostböck, Sven ; Männel, Daniela N.
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Date of publication of this fulltext: 26 Aug 2016 05:37


Sepsis-induced immune reactions are reduced in TNF receptor 2 (TNFR2)-deficient mice as previously shown. In order to elucidate the underlying mechanisms, the functional integrity of myeloid cells of TNFR2-deficient mice was analyzed and compared to wild type (WT) mice. The capacity of dendritic cells to produce IL-12 was strongly impaired in TNF-deficient mice, mirroring impaired production of ...


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