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Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

Henrich, F., Singer, Katrin, Poller, K., Bernhardt, L., Strobl, C., Ritter, Axel P., Gottfried, E., Peter, Katrin, Dettmer, Katja, Oefner, Peter J., Bosserhoff, Anja-Katrin and Kreutz, Marina (2016) Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells. OncoImmunology 5, e1184802.

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The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites such as 5′-deoxy-5′-methylthioadenosine (MTA). Increased intratumoral MTA levels result from a lack of the MTA-catabolizing enzyme methylthioadenosine phosphorylase (MTAP) in tumor cells and are found in various tumor entities. ...


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Item type:Article
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
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Keywords:Antitumor immune response, cell signaling, immunosuppression, MTA, MTAP, protein methylation, tumor metabolism, T cells
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34525
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