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Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

Henrich, F. ; Singer, Katrin ; Poller, K. ; Bernhardt, L. ; Strobl, C. ; Ritter, Axel P. ; Gottfried, E. ; Peter, Katrin ; Dettmer, Katja ; Oefner, Peter J. ; Bosserhoff, Anja-Katrin ; Kreutz, Marina



Abstract

The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites such as 5'-deoxy-5'-methylthioadenosine (MTA). Increased intratumoral MTA levels result from a lack of the MTA-catabolizing enzyme methylthioadenosine phosphorylase (MTAP) in tumor cells and are found in various tumor entities. ...

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