Assessment of Different Expression Strategies for the Production of a Recombinant Lipoprotein Vaccine in Plants

URN to cite this document:: urn:nbn:de:bvb:355-epub-345373
DOI to cite this document:: 10.5283/epub.34537

Hennig, A. ; Reinders, Yvonne ; Giritch, A. ; Reinders, Jörg ; Warzecha, H.

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Date of publication of this fulltext: 07 Sep 2016 08:03

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Abstract

The ability of plants to serve as a production system for bacterial lipoprotein vaccines has been investigated. First, the effect of high-level expression of the Borrelia burgdorferi outer membrane protein A (OspA), a prototype vaccine against Lyme disease, has been examined by a proteomics approach. Analysis by 2D-PAGE of wild type tobacco plants and transplastomic plants accumulating ...