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Traces of molecular disease mechanisms on microarrays

Lottaz, Claudio, Kostka, Dennis, Markowetz, Florian and Spang, Rainer (2005) Traces of molecular disease mechanisms on microarrays. Methods in Molecular Biology 453, pp. 281-296.

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Abstract

Gene expression profiling using micro-arrays is a modern approach for molecular diagnostics. In clinical micro-array studies, researchers aim to predict disease type, survival, or treatment response using gene expression profiles. In this process, they encounter a series of obstacles and pitfalls. This chapter reviews fundamental issues from machine learning and recommends a procedure for the computational aspects of a clinical micro-array study.


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Item type:Article
Date:2005
Additional Information (public):ISNB 978-1-60327-428-9
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1007/978-1-60327-429-6_15DOI
Keywords:Micro-arrays; gene expression profiles; statistical classification; supervised machine learning; gene selection; model assessment
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34540
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