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Traces of molecular disease mechanisms on microarrays

Lottaz, Claudio ; Kostka, Dennis ; Markowetz, Florian ; Spang, Rainer


Gene expression profiling using micro-arrays is a modern approach for molecular diagnostics. In clinical micro-array studies, researchers aim to predict disease type, survival, or treatment response using gene expression profiles. In this process, they encounter a series of obstacles and pitfalls. This chapter reviews fundamental issues from machine learning and recommends a procedure for the computational aspects of a clinical micro-array study.

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