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Traces of molecular disease mechanisms on microarrays

Lottaz, Claudio, Kostka, Dennis, Markowetz, Florian and Spang, Rainer (2005) Traces of molecular disease mechanisms on microarrays. Methods in Molecular Biology 453, pp. 281-296.

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Gene expression profiling using micro-arrays is a modern approach for molecular diagnostics. In clinical micro-array studies, researchers aim to predict disease type, survival, or treatment response using gene expression profiles. In this process, they encounter a series of obstacles and pitfalls. This chapter reviews fundamental issues from machine learning and recommends a procedure for the computational aspects of a clinical micro-array study.

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Item type:Article
Additional Information (public):ISNB 978-1-60327-428-9
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
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Keywords:Micro-arrays; gene expression profiles; statistical classification; supervised machine learning; gene selection; model assessment
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34540
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