Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder

URN to cite this document:: urn:nbn:de:bvb:355-epub-345605
DOI to cite this document:: 10.5283/epub.34560

Frodl, T. ; Carballedo, A. ; Frey, Eva-Maria ; O'Keane, V. ; Skokauskas, N. ; Morris, D. ; Gill, M. ; Hughes, M. ; Harkin, A. ; Connor, T.

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Date of publication of this fulltext: 18 Oct 2016 11:57

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Abstract

Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate gyrus subfields. Forty-three patients with MDD and 43 ...