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Polyanions effectively prevent protein conjugation and activity loss during hydrogel cross-linking

Gregoritza, Manuel, Goepferich, Achim and Brandl, Ferdinand (2016) Polyanions effectively prevent protein conjugation and activity loss during hydrogel cross-linking. Journal of Controlled Release 238, pp. 92-102.

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Abstract

In situ encapsulation is a frequently used method to prepare hydrogels loaded with high quantities of therapeutic proteins. However, many cross-linking reactions, such as Michael-type addition or Diels–Alder (DA) reaction are not tolerant toward nucleophiles; therefore, side-reactions with proteins can occur during cross-linking. This may lead to undesired protein conjugation, activity loss and ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.jconrel.2016.07.030DOI
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34661
Owner only: item control page
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