Expression of BMP and Actin Membrane Bound Inhibitor (BAMBI) is increased during terminal differentiation of MSCs

URN to cite this document:: urn:nbn:de:bvb:355-epub-347321
DOI to cite this document:: 10.5283/epub.34732

Pfeifer, Christian G. ; Karl, Alexandra ; Berner, Arne ; Zellner, Johannes ; Schmitz, Paul ; Loibl, Markus

; Koch, Matthias ; Angele, Peter ; Nerlich, Michael ; Mueller, Michael B.

Preview

PDF
(4MB)

Date of publication of this fulltext: 29 Nov 2016 12:14

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossification and become hypertrophic. BMP (bone morphogenetic protein) and Activin Membrane Bound Inhibitor (BAMBI) is a pseudoreceptor that regulates the activity of transforming growth factor-beta (TGF-beta) and BMP signalling during chondrogenesis. Both TGF-beta and BMP signalling are regulators of ...