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Expression of BMP and Actin Membrane Bound Inhibitor (BAMBI) is increased during terminal differentiation of MSCs

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Pfeifer, Christian G. ; Karl, Alexandra ; Berner, Arne ; Zellner, Johannes ; Schmitz, Paul ; Loibl, Markus ; Koch, Matthias ; Angele, Peter ; Nerlich, Michael ; Mueller, Michael B.
Date of publication of this fulltext: 29 Nov 2016 12:14


Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossification and become hypertrophic. BMP (bone morphogenetic protein) and Activin Membrane Bound Inhibitor (BAMBI) is a pseudoreceptor that regulates the activity of transforming growth factor-beta (TGF-beta) and BMP signalling during chondrogenesis. Both TGF-beta and BMP signalling are regulators of ...


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