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The anti-inflammatory effects of E-α-(p-methoxyphenyl)-2′,3,4,4′-tetramethoxychalcone are mediated via HO-1 induction

Kaufmann, Kai B., Gothwal, Monika, Schallner, Nils, Ulbrich, Felix, Rücker, Hannelore-Maria, Amslinger, Sabine and Goebel, Ulrich (2016) The anti-inflammatory effects of E-α-(p-methoxyphenyl)-2′,3,4,4′-tetramethoxychalcone are mediated via HO-1 induction. International Immunopharmacology 35, pp. 99-110.

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Other URL: http://doi.org/10.1016/j.intimp.2016.03.018


Abstract

Inflammation plays a central role in the pathophysiology of many diseases. The inducible enzyme heme oxygenase-1 (HO-1) protects cells against inflammation and can be induced by electrophilic compounds like the chalcones (1,3-diphenylprop-2-enones) from the class of α,β-unsaturated carbonyl compounds. We hypothesized that the synthetic chalcone E-α-(p-methoxyphenyl)-2′,3,4,4′-tetramethoxychalcone ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1016/j.intimp.2016.03.018DOI
Keywords:Chalcone; HO-1; Inflammation; Nrf2; NF-κB; MAPK
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35008
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