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The anti-inflammatory effects of E-α-(p-methoxyphenyl)-2′,3,4,4′-tetramethoxychalcone are mediated via HO-1 induction

Kaufmann, Kai B. ; Gothwal, Monika ; Schallner, Nils ; Ulbrich, Felix ; Rücker, Hannelore-Maria ; Amslinger, Sabine ; Goebel, Ulrich



Abstract

Inflammation plays a central role in the pathophysiology of many diseases. The inducible enzyme heme oxygenase-1 (HO-1) protects cells against inflammation and can be induced by electrophilic compounds like the chalcones (1,3-diphenylprop-2-enones) from the class of alpha,beta-unsaturated carbonyl compounds. We hypothesized that the synthetic chalcone ...

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