In these lecture notes we study the disordered two-dimensional electron gas in the presence of Rashba spin-orbit coupling, by using the Keldysh non-equilibrium Green function technique. We describe the effects of the spin-orbit coupling in terms of a SU(2) gauge field and derive a generalized Boltzmann equation for the charge and spin distribution functions. We then apply the formalism to discuss the spin Hall and the inverse spin galvanic (Edelstein) effects. Successively we show how to include, within the generalized Boltzmann equation, the side jump, the skew scattering and the spin current swapping processes originating from the extrinsic spin-orbit coupling due to impurity scattering.