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Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure

Grois, Laura, Hupf, Julian, Reinders, Jörg, Schröder, Josef, Dietl, Alexander, Schmid, Peter M., Jungbauer, Carsten, Resch, Markus, Maier, Lars S., Luchner, Andreas and Birner, Christoph (2017) Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure. PLoS ONE 12 (1), e0169743.

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Date of publication of this fulltext: 16 Jan 2017 13:15

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Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169743

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Abstract

Background Inhibitors of the renin angiotensin system and neprilysin (RAS-/NEP-inhibitors) proved to be extraordinarily beneficial in systolic heart failure. Furthermore, compelling evidence exists that impaired mitochondrial pathways are causatively involved in progressive left ventricular (LV) dysfunction. Consequently, we aimed to assess whether RAS-/NEP-inhibition can attenuate mitochondrial ...

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Item type:Article
Date:11 January 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin II
Medicine > Lehrstuhl für Pathologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
28076404PubMed ID
10.1371/journal.pone.0169743DOI
Article-ID: e0169743Other
Keywords:PRESERVED EJECTION FRACTION; CARDIOMYOPATHIC HAMSTERS; DIFFERENTIAL EXPRESSION; OXIDATIVE STRESS; NERVOUS-SYSTEM; DYSFUNCTION; OMAPATRILAT; TRIAL; PATHOPHYSIOLOGY; METABOLISM;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35049
Owner only: item control page

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