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Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure

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Grois, Laura ; Hupf, Julian ; Reinders, Jörg ; Schröder, Josef ; Dietl, Alexander ; Schmid, Peter M. ; Jungbauer, Carsten ; Resch, Markus ; Maier, Lars S. ; Luchner, Andreas ; Birner, Christoph
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Jan 2017 13:15


Background Inhibitors of the renin angiotensin system and neprilysin (RAS-/NEP-inhibitors) proved to be extraordinarily beneficial in systolic heart failure. Furthermore, compelling evidence exists that impaired mitochondrial pathways are causatively involved in progressive left ventricular (LV) dysfunction. Consequently, we aimed to assess whether RAS-/NEP-inhibition can attenuate mitochondrial ...


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