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Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells

Roider, Tobias, Katzfuss, Michael, Matos, Carina, Singer, Katrin, Renner, Kathrin, Oefner, Peter , Dettmer-Wilde, Katja, Herr, Wolfgang, Holler, Ernst, Kreutz, Marina and Peter, Katrin (2016) Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells. International Journal of Molecular Sciences 17, p. 2081.

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Date of publication of this fulltext: 23 Jan 2017 12:33

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Other URL: http://www.mdpi.com/1422-0067/17/12/2081


Abstract

Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon®) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype in ...

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Item type:Article
Date:December 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
27973435PubMed ID
10.3390/ijms17122081DOI
PMC5187881PubMedCentral-ID
Keywords:Grafalon; allogeneic hematopoietic stem cell transplantation; antithymocyte globulin; dendritic cell; immunosuppressive; indoleamine 2,3-dioxygenase; tolerogenic
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35078
Owner only: item control page

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