Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-350786
DOI to cite this document:: 10.5283/epub.35078

Roider, Tobias ; Katzfuss, Michael ; Matos, Carina ; Singer, Katrin ; Renner, Kathrin ; Oefner, Peter

; Dettmer-Wilde, Katja ; Herr, Wolfgang ; Holler, Ernst ; Kreutz, Marina

; Peter, Katrin

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Date of publication of this fulltext: 23 Jan 2017 12:33

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Abstract

Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon (R)) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype ...