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Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells

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Roider, Tobias ; Katzfuss, Michael ; Matos, Carina ; Singer, Katrin ; Renner, Kathrin ; Oefner, Peter ; Dettmer-Wilde, Katja ; Herr, Wolfgang ; Holler, Ernst ; Kreutz, Marina ; Peter, Katrin
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 Jan 2017 12:33


Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon (R)) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype ...


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