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Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration

Grassmann, Felix , Heid, Iris M. and Weber, Bernhard H. F. (2017) Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration. Genetics 205 (2), pp. 919-924.

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Date of publication of this fulltext: 27 Jan 2017 15:20

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Other URL: http://doi.org/10.1534/genetics.116.195966


Age-related macular degeneration (AMD) is the leading cause of blindness in ageing societies, triggered by both environmental and genetic factors. The strongest genetic signal for AMD with odds ratios of up to 2.8 per adverse allele was found previously over a chromosomal region in 10q26 harboring two genes, ARMS2 and HTRA1, although with little knowledge as to which gene or genetic variation is ...


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Item type:Article
Date:February 2017
Institutions:Medicine > Lehrstuhl für Humangenetik
Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Identification Number:
27879347PubMed ID
Keywords:CHROMOSOME 10Q26; MESSENGER-RNA; HTRA1; ARMS2; SUSCEPTIBILITY; VARIANTS; COMPLEMENT; LOC387715; IMPAIR; RISK; age-related macular degeneration; genetic association studies; linkage disequilibrium; haplotypes; ARMS2/HTRA1 gene locus
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35108
Owner only: item control page


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