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Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

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Längst, Gernot ; Silberhorn, Elisabeth ; Schwartz, Uwe ; Löffler, Patrick ; Schmitz, Samuel ; Symelka, Anne ; Koning-Ward, Tania de ; Merkl, Rainer
Date of publication of this fulltext: 10 Feb 2017 07:40


The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nucleosomes in vivo are thought to depend on the biophysical properties of the histones, sequence patterns, like phased di-nucleotide repeats and the ...


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