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In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC)

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Brandl, Caroline ; Zimmermann, Stephanie J. ; Milenkovic, Vladimir M. ; Rosendahl, S. M. ; Grassmann, Felix ; Milenkovic, Andrea ; Hehr, Ute ; Federlin, Marianne ; Wetzel, Christian H. ; Helbig, Horst ; Weber, Bernhard H. F.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Feb 2017 12:43


Induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) has widely been appreciated as a promising tool to model human ocular disease emanating from primary RPE pathology. Here, we describe the successful reprogramming of adult human dermal fibroblasts to iPSCs and their differentiation to pure expandable RPE cells with structural and functional features characteristic for ...


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