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In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC)

Brandl, Caroline, Zimmermann, Stephanie J., Milenkovic, Vladimir M., Rosendahl, S. M., Grassmann, Felix, Milenkovic, Andrea, Hehr, Ute, Federlin, Marianne, Wetzel, Christian H., Helbig, Horst and Weber, Bernhard H. F. (2014) In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC). NeuroMolecular Medicine 16, pp. 551-564.

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Date of publication of this fulltext: 08 Feb 2017 12:43

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Abstract

Induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) has widely been appreciated as a promising tool to model human ocular disease emanating from primary RPE pathology. Here, we describe the successful reprogramming of adult human dermal fibroblasts to iPSCs and their differentiation to pure expandable RPE cells with structural and functional features characteristic for ...

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Item type:Article
Date:2014
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Medicine > Lehrstuhl für Humangenetik
Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften
Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie
Identification Number:
ValueType
10.1007/s12017-014-8308-8DOI
24801942PubMed ID
Keywords:Induced pluripotent stem cell; Retinal pigment epithelium; Dermal fibroblast; Bestrophin-1; BEST1
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35173
Owner only: item control page

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