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Seven new loci associated with age-related macular degeneration

Fritsche, Lars G. ; Chen, W. ; Schu, M. ; Weber, Bernhard H. F. ; et, al.



Abstract

Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 x 10(-8) These loci show enrichment ...

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