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Mapping and genomic characterization of the gene encoding diacylglycerol kinase γ (DAGK3): assessment of its role in dominant optic atrophy (OPA1)

Stöhr, H. ; Klein, J. ; Gehrig, A. ; Koehler, M. R. ; Jurklies, B. ; Kellner, U. ; Leo-Kottler, B. ; Schmid, M. ; Weber, Bernhard H. F.


The family of diacylglycerol kinases (DAGKs) is known to play an important role in signal transduction linked to phospholipid turnover. In the fruitfly Drosophila melanogaster, a human DAGK ortholog, DGK2, was shown to underlie the phenotype of the visual mutant retinal degeneration A (rdgA). Previously, the gene encoding a novel member of the human DAGK family, termed DAGK3, was cloned and ...


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