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Frequency of BRCA1 mutation 5382insC in german breast cancer patients

Backe, J. ; Hofferbert, S. ; Skawran, B. ; Dörk, T. ; Stuhrmann, M. ; Karstens, J. H. ; Untch, M. ; Meindl, A. ; Burgemeister, R. ; Chang-Claude, J. ; Weber, Bernhard H. F.


Objective.The aim of the study was to determine the frequency of the BRCA1 mutation 5382insC in German breast cancer patients with and without prior knowledge of a family history of breast cancer. Methods.Two groups of breast cancer patients were tested for the presence or absence of the 5382insC mutation using a PCR primer mismatch assay. A sample of 248 patients unrelated by genealogy was ...


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