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Linkage disequilibrium and modification of risk for Huntington disease

Adam, S. ; Theilmann, J. ; Buetow, K. ; Hedrick, A. ; Collins, C. ; Weber, Bernhard H. F. ; Huggins, M. ; Hayden, M.


The major limitation in performing predictive testing for Huntington disease (HD) is the unavailability of DNA from crucial family members. In our program approximately 20% (36/183) of persons have been excluded from predictive testing because of this reason. The major aim of this study was to examine whether data derived from linkage disequilibrium could modify risk analysis for persons at risk ...


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