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Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma

Keller, Max , Maschauer, Simone, Brennauer, Albert, Tripal, Philipp, Koglin, Norman, Dittrich, Ralf, Bernhardt, Günther, Kuwert, Torsten, Wester, Hans-Jürgen, Buschauer, Armin and Prante, Olaf (2017) Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma. ACS Medicinal Chemistry Letters 8, pp. 304-309.

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Other URL: http://dx.doi.org/10.1021/acsmedchemlett.6b00467


Abstract

The neuropeptide Y (NPY) Y-1, receptor (Y-1,R) selective radioligand (R)-N-a -(2,2-diphenylacety1)N-omega-[4(2[F-18]fluoropropanoylamino)butyllaminocarbonyl-N-(4-hydroxybenzy1)-argininamide ([F-18]23), derived from the high-affinity Y-1,R antagonist BIBP3226, was developed for imaging studies of Y-1,R-positive tumors. Starting from the argininamide core bearing amine-functionalized spacer ...

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Item type:Article
Date:21 February 2017
Additional Information (public):Supporting information available online
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1021/acsmedchemlett.6b00467DOI
28337321PubMed ID
Keywords:Y-1 RECEPTOR ANTAGONISTS; ACYLGUANIDINE BIOISOSTERIC APPROACH; POSITRON-EMISSION-TOMOGRAPHY; TARGETED TUMOR-DIAGNOSIS; BREAST-CANCER; PEPTIDE-HORMONES; HIGHLY POTENT; THERAPY; NEUROTENSIN; ANALOGS; Fluorine-18; antagonist; positron emission tomography; PET; neuropeptide Y; NPY; Y1R
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35318
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