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Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma

Keller, Max ; Maschauer, Simone ; Brennauer, Albert ; Tripal, Philipp ; Koglin, Norman ; Dittrich, Ralf ; Bernhardt, Günther ; Kuwert, Torsten ; Wester, Hans-Jürgen ; Buschauer, Armin ; Prante, Olaf



Abstract

The neuropeptide Y (NPY) Y-1, receptor (Y-1,R) selective radioligand (R)-N-a -(2,2-diphenylacety1)N-omega-[4(2[F-18]fluoropropanoylamino)butyllaminocarbonyl-N-(4-hydroxybenzy1)-argininamide ([F-18]23), derived from the high-affinity Y-1,R antagonist BIBP3226, was developed for imaging studies of Y-1,R-positive tumors. Starting from the argininamide core bearing amine-functionalized spacer ...

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