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Genomic organization and complete sequence of the human gene encoding the β-subunit of the cGMP phosphodiesterase and its localisation to 4p16.3

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Weber, Bernhard H. F. ; Riess, O. ; Hutchinson, G. ; Collins, C. ; Lin, B. ; Kowbel, D. ; Andrew, S. ; Schappert, K. ; Hayden, M. R.
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Date of publication of this fulltext: 23 Mar 2017 11:32


As part of the search for the Huntington disease (HD) gene we have cloned and sequenced 34 kb of genomic DNA containing the full-length gene for the β-subunit of the human cGMP phosphodiesterase (β-cGMP PDE). This gene is localized to 4p16.3 about 700 kb proximal to the 4p telomere and represents the most telomeric gene characterized on 4p to date. We show that this gene is comprised of 22 exons ...


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