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Nonrandom association between huntington disease and two loci separated by about 3 Mb on 4p16.3

Andrew, S. ; Theilmann, J. ; Hedrick, A. ; Mah, D. ; Weber, Bernhard H. F. ; Hayden, M. R.


The gene for Huntington disease (HD) has been localized close to the telomere on the short arm of chromosome 4. However, refined mapping using recombinant HD chromosomes has resulted in conflicting findings and mutually exclusive candidate regions. Previously reported significant nonrandom allelic association between D4S95 and HD provided support for a more proximal location for the defective ...


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