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Die Rolle des TGF-β-Signalweges bei pathologischen Veränderungen der Netzhaut

Etzel, Sarah Verena (2018) Die Rolle des TGF-β-Signalweges bei pathologischen Veränderungen der Netzhaut. PhD, Universität Regensburg.

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Date of publication of this fulltext: 21 Mar 2017 10:17

Abstract (German)

Die konditionellen TGF-β-Rezeptor-Typ 2- Defizienten Tiere (Tgfbr2Δeye) zeigen viele morphologische Gemeinsamkeiten mit der menschlichen diabetischen Retinopathie. Unter anderem treten Mikroaneurysmen, Kapillarlekagen, Glaskörperblutungen, harte Exsudate, Cotton-Wool-Herde, Neovaskularisationen des Glaskörpers sowie Netzhautablösungen auf. Typische proangiogene Faktoren sind erhöht. Andererseits ...

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Translation of the abstract (English)

The molecular pathogenesis of neovascularization, an angiogenic process that critically contributes to vision loss in age-related macular degeneration (AMD) and diabetic retinopathy (DR) is unclear. To identify the role of TGF-β signaling for the formation of neovascularization, we generated mice with a conditional deletion of the TGF-β type II (TβRII) receptor which is essential for TGF-β ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:March 2018
Referee:Prof. Dr. Ernst Rudolf Tamm
Date of exam:22 February 2017
Institutions:Medicine > Lehrstuhl für Humangenetik
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Keywords:diabetische Retinopathie (DRP), altersbedingte Makuladegeneration (AMD), konditionelle Defizienz des TβR2 Diabetic retinopathy (DRP), age-related maculopathy (AMD), conditional deletion of Tgfbr2
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35438
Owner only: item control page

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