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Effekte von 2-Hydroxyglutarat auf humane Immunzellen

URN to cite this document:
urn:nbn:de:bvb:355-epub-354617
Ugele, Ines Marion
Date of publication of this fulltext: 13 Apr 2017 09:42


Abstract (German)

Somatische Mutationen der Isozitratdehydrogenase (IDH) 1 und 2 wurden in verschiedenen Tumorentitäten nachgewiesen. Das mutierte Enzym IDH1/2 erlangte die Fähigkeit, α-Ketoglutarat in den Onkometaboliten 2-Hydroxyglutarat (2-HG) zu konvertieren. Bei der akuten myeloischen Leukämie (AML) ist bekannt, dass die Mutation der IDH1/2 positiv mit der Tumorprogression und einem schlechteren Outcome ...

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Translation of the abstract (English)

As you know, tumor metabolism is modified in many ways, for example the changes in the glucose metabolism, described with the warburg effect. It is known that a lot of lactate is produced by tumor cells. This is due to for example the upregulation of oncogenes and the loss of tumor suppressor genes. Furthermore, there are mutations in the succinate Dehydrogenase, fumarate hydrogenase and ...

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