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Synthesis and pharmacological characterization of homo- and hetero-dimeric compounds, targeting the hH₁R and/or hH₄R

Wan, Jianfei (2017) Synthesis and pharmacological characterization of homo- and hetero-dimeric compounds, targeting the hH₁R and/or hH₄R. PhD, Universität Regensburg.

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Date of publication of this fulltext: 30 Mar 2017 07:59

Abstract (English)

G-protein coupled receptors are the most important class of biological targets for drug development. Among them, the histamine receptors may be considered as representative examples for aminergic GPCRs. The latest member of the histamine receptor family, the H4R, was reported to be involved in immunological processes and inflammatory diseases. However, the (patho)physiological role of the H4R is ...

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Translation of the abstract (German)

G-Protein-gekoppelte Rezeptoren sind die wichtigste Klasse biologischer Ziele für die Arzneimittelentwicklung. Unter ihnen können die Histaminrezeptoren als repräsentative Beispiele für aminergische GPCRs angesehen werden. Das jüngste Mitglied der Histamin-Rezeptor-Familie, das H4R, wurde berichtet, dass es an immunologischen Prozessen und entzündlichen Erkrankungen beteiligt ist. Allerdings ist ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:30 March 2017
Referee:PD. Dr. Andrea Straßer and Prof. Dr. Armin Buschauer
Date of exam:24 March 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:hH1R, hH4R, dual receptor ligands
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35470
Owner only: item control page

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