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Polyanion based controlled release system for the GnRH-receptor antagonist degarelix

Backofen, Michael, Schwach, Gregoire, Koechling, Wolfgang, Weiss, Torsten and Goepferich, Achim (2017) Polyanion based controlled release system for the GnRH-receptor antagonist degarelix. European Journal of Pharmaceutical Sciences 104, pp. 65-71.

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Abstract

The aim of this study was to investigate the interaction between the positively charged gonadotropin releasing hormone receptor antagonist degarelix and the two polyanions alginate and carboxymethyl cellulose (CMC). Light as well as transmission electron microscopy revealed that complexes formed by simple mixing of the peptide with one of the polymers had a nano-structure consisting of twisted ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejps.2017.03.036DOI
Keywords:SUSTAINED-RELEASE; PROSTATE-CANCER; IN-VITRO; MICROPARTICLES; FORMULATION; PEPTIDES; PLGA; ACID; PH; GnRH antagonist; Sustained release; Polymer complex; ITC; TEM; In-vitro study
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35541
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