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Polyanion based controlled release system for the GnRH-receptor antagonist degarelix

Backofen, Michael ; Schwach, Gregoire ; Koechling, Wolfgang ; Weiss, Torsten ; Goepferich, Achim



Abstract

The aim of this study was to investigate the interaction between the positively charged gonadotropin releasing hormone receptor antagonist degarelix and the two polyanions alginate and carboxymethyl cellulose (CMC). Light as well as transmission electron microscopy revealed that complexes formed by simple mixing of the peptide with one of the polymers had a nano-structure consisting of twisted ...

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