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An optimized IFN-γ ELISpot assay for the sensitive and standardized monitoring of CMV protein-reactive effector cells of cell-mediated immunity

Rascle, Anne, Barabas, Sascha, Spindler, Theresa, Kiener, Richard, Tonar, Charlotte, Lugner, Tamara, Batzilla, Julia, Bendfeldt, Hanna, Asbach, Benedikt, Wagner, Ralf and Deml, Ludwig (2017) An optimized IFN-γ ELISpot assay for the sensitive and standardized monitoring of CMV protein-reactive effector cells of cell-mediated immunity. BMC Immunology 18 (14), pp. 1-15.

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Date of publication of this fulltext: 21 Apr 2017 14:31

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Other URL: https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-017-0195-y

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Background: In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cell-mediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to uncontrolled CMV replication and severe clinical complications. Close monitoring of CMV-specific CMI is therefore clinically relevant and might allow a reliable prognosis of CMV ...

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Item type:Article
Date:7 March 2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12865-017-0195-yDOI
Keywords:CD8 T-CELLS; KIDNEY-TRANSPLANT RECIPIENTS; SOLID-ORGAN TRANSPLANTATION; LINKED IMMUNOSORBENT SPOT; CYTOMEGALOVIRUS-SPECIFIC CD4(+); NK CELLS; RENAL-TRANSPLANTATION; FUNCTIONAL IMPAIRMENT; DENDRITIC CELLS; PREGNANT-WOMEN; Cytomegalovirus; CMV; IE-1; pp65; Cell-mediated immunity; ELISpot; CD4(+); CD8(+); T helper (Th); Cytotoxic T lymphocyte (CTL); Natural killer (NK); NKT-like
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35576
Owner only: item control page

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