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Characterization of the Neuroprotective Function of the TGF-β Signaling Pathway in the Retina

Boneva, Stefaniya Konstantinova (2018) Characterization of the Neuroprotective Function of the TGF-β Signaling Pathway in the Retina. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Feb 2018 09:36

Abstract (English)

The aim of this work was to demonstrate the neuroprotective role of TGF-β signaling on photoreceptors in the adult retina and to investigate the molecular mechanisms, mediating this effect. The assessment of this notion included the generation of transgenic mice, bearing a TβRII deficiency in different subpopulations of retinal cells. The deletion of TGF-β signaling in retinal neurons and Müller ...

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Translation of the abstract (German)

Die Zielsetzung dieser Arbeit bestand in der Darlegung der neuroprotektiven Rolle des TGF-β-Signalweges auf Photorezeptoren in der adulten Netzhaut und in der Erforschung der molekularen Mechanismen, welche den Effekt vermitteln. Zu der Überprüfung dieser Hypothese gehörte das Generieren von konditionellen Knockout-Mäusen, die eine Deletion des TβRII in unterschiedlichen Subpopulationen retinaler ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:26 February 2018
Referee:PD Dr. Dr. Barbara Braunger and Prof. Dr. Frank Schweda
Date of exam:24 February 2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Keywords:retina, photoreceptors, neuroprotection, TGF-β, light damage
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35581
Owner only: item control page

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