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Characterization of the Neuroprotective Function of the TGF-β Signaling Pathway in the Retina

URN to cite this document:
urn:nbn:de:bvb:355-epub-355810
DOI to cite this document:
10.5283/epub.35581
Boneva, Stefaniya Konstantinova
Date of publication of this fulltext: 26 Feb 2018 09:36


Abstract (English)

The aim of this work was to demonstrate the neuroprotective role of TGF-β signaling on photoreceptors in the adult retina and to investigate the molecular mechanisms, mediating this effect. The assessment of this notion included the generation of transgenic mice, bearing a TβRII deficiency in different subpopulations of retinal cells. The deletion of TGF-β signaling in retinal neurons and Müller ...

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Translation of the abstract (German)

Die Zielsetzung dieser Arbeit bestand in der Darlegung der neuroprotektiven Rolle des TGF-β-Signalweges auf Photorezeptoren in der adulten Netzhaut und in der Erforschung der molekularen Mechanismen, welche den Effekt vermitteln. Zu der Überprüfung dieser Hypothese gehörte das Generieren von konditionellen Knockout-Mäusen, die eine Deletion des TβRII in unterschiedlichen Subpopulationen retinaler ...

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