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Evolution of substrate specificity and protein-protein interactions in three enzyme superfamilies

Plach, Maximilian (2017) Evolution of substrate specificity and protein-protein interactions in three enzyme superfamilies. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 May 2017 09:29

Abstract (English)

Superfamilies are a classification system to combine proteins that are related through a common evolutionary origin, share similar sequences, structures, and core reaction mechanisms, but exert different functions. Today, for most superfamilies tens of thousands of sequences and hundreds of structures are known and most of the different functions of their members have been elucidated. ...

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Translation of the abstract (German)

Superfamilien stellen ein Klassifikationsschema zur Gruppierung von Proteinen dar, die auf einen gemeinsamen evolutionären Ursprung zurück gehen und Ähnlichkeiten in Sequenz, Struktur und Reaktionsmechanismus besitzen, jedoch unterschiedliche Funktionen ausüben. Die meisten Superfamilien sind heute umfassend charakterisiert und häufig sind für eine Superfamilie mehr als zehntausend Sequenzen, ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 May 2017
Referee:Prof. Dr. Reinhard Sterner
Date of exam:28 April 2017
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Keywords:enzyme evolution, Enzymevolution, protein evolution, Proteinevolution, superfamilies, Superfamilien, chorismate-utilizing enzymes, Chorismat-umsetzende Enzyme, ancestral sequence reconstruction, Rekonstruktion anzestraler Sequenzen, bi-functionality, Bifunktionalität, enzyme catalysis, Enzymkatalyse, nucleophile specificity, Nukleophilspezifität, enzyme channels, Tunnel in Enzymen, protein-protein interactions, Protein-Protein Interaktionen, protein interfaces, Proteinkontaktflächen, protein structure, Proteinstruktur
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35596
Owner only: item control page

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