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Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin

Weissert, Robert and ‘t Hart, Bert A. (2016) Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin. Multiple Sclerosis Journal – Experimental, Translational and Clinical 2, pp. 1-5.

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Date of publication of this fulltext: 05 May 2017 12:33

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Abstract

Background Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. Objective We propose that MOG has a central role in the regulation of tolerance and autoimmunity. Conclusion The interaction of MOG with DC-SIGN, an ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.1177/2055217316630999DOI
Keywords:Multiple sclerosis, antigen-presenting cells, tolerance, autoantigen, glycosylation, danger, regulation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35617
Owner only: item control page

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