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Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin

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Weissert, Robert ; ‘t Hart, Bert A.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 05 May 2017 12:33


Background Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. Objective We propose that MOG has a central role in the regulation of tolerance and autoimmunity. Conclusion The interaction of MOG with DC-SIGN, an ...


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