Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin

URN to cite this document:: urn:nbn:de:bvb:355-epub-356173
DOI to cite this document:: 10.5283/epub.35617

Weissert, Robert

; ‘t Hart, Bert A.

Preview

License: Allianz- bzw. Nationallizenz
PDF - Published Version
(242kB)

Date of publication of this fulltext: 05 May 2017 12:33

Alternative links to fulltext:DOI

Details

Preview

Export bibliographical data

Abstract

Background Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. Objective We propose that MOG has a central role in the regulation of tolerance and autoimmunity. Conclusion The interaction of MOG with DC-SIGN, an ...