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The Role of Cyclooxygenase-1 and -2 in Sevoflurane-Induced Postconditioning Against Myocardial Infarction

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Stumpner, J. ; Tischer-Zeitz, T. ; Frank, Anja ; Lotz, Christopher ; Redel, Andreas
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 11 May 2017 13:43


Cyclooxygenase (COX)-2 mediates ischemic pre- and postconditioning as well as anesthetic-induced preconditioning. However, the role of COX-1 and -2 in anesthetic-induced postconditioning has not been investigated. We evaluated the role of COX-1 and -2 in sevoflurane-induced postconditioning in vivo. Pentobarbital-anaesthetized male C57BL/6 mice were subjected to 45 minutes of coronary artery ...


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