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Photochromic histone deacetylase inhibitors based on
dithienylethenes and fulgimides

Wutz, Daniel-Fabian, Gluhacevic, Dino, Chakrabarti, A., Schmidtkunz, K., Robaa, D., Erdmann, F., Romier, C., Sippl, W., Jung, M. and König, Burkhard (2017) Photochromic histone deacetylase inhibitors based on
dithienylethenes and fulgimides.
Organic & Biomolecular Chemistry 15, pp. 4882-4896.

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Abstract

Histone deacetylases (HDACs) play a crucial role in numerous biological processes and therefore are targeted in anticancer research and in the field of epigenetics. Dithienylethenes (DTEs) and fulgimides were functionalized with hydroxamic acids, which is a known moiety binding to zinc dependent HDACs, to gain photoswitchable HDAC inhibitors. The new DTE based inhibitors showed moderate ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:ERASynBio project Modulightor
Identification Number:
ValueType
10.1039/C7OB00976CDOI
Keywords:Photopharmacology
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35672
Owner only: item control page
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