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Photochromic histone deacetylase inhibitors based on
dithienylethenes and fulgimides

Wutz, Daniel-Fabian ; Gluhacevic, Dino ; Chakrabarti, A. ; Schmidtkunz, K. ; Robaa, D. ; Erdmann, F. ; Romier, C. ; Sippl, W. ; Jung, M. ; König, Burkhard



Abstract

Histone deacetylases (HDACs) play a crucial role in numerous biological processes and therefore are targeted in anticancer research and in the field of epigenetics. Dithienylethenes (DTEs) and fulgimides were functionalized with hydroxamic acids, which is a known moiety binding to zinc dependent HDACs, to gain photoswitchable HDAC inhibitors. The new DTE based inhibitors showed moderate ...

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