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DNA analysis of Huntington's disease: five year experience in Germany, Austria and Switzerland (1993-1997)

Laccone, F. ; Engel, U. ; Holinski-Feder, E. ; Weigell-Weber, M. ; Marczinek, K. ; Nolte, D. ; Morris-Rosendahl, D. J. ; Zühlke, C. ; Fuchs, K. ; Weirich-Schwaiger, H. ; Schluter, G. ; von Beust, G. ; Vieira-Saecker, A. M. ; Weber, Bernhard H. F. ; Riess, O.


Objective: To review the direct DNA testing for Huntington’s disease (HD) in Germany, Switzerland, and Austria from 1993 to 1997, and to analyze the population with regard to age structure, gender, and family history. Methods: Twelve laboratories (nine in Germany, two in Austria, and one in Switzerland) recorded data pertaining to repeat number, gender, age at molecular diagnosis, and family ...


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