An update on the genetics of age-related macular degeneration

URN to cite this document:: urn:nbn:de:bvb:355-epub-358443
DOI to cite this document:: 10.5283/epub.35844

Scholl, H. P. ; Fleckenstein, M. ; Issa, P. C. ; Keilhauer, C. ; Holz, F. G. ; Weber, Bernhard H. F.

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Date of publication of this fulltext: 07 Jul 2017 08:42

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Abstract

Age-related macular degeneration (AMD) is a genetically complex disorder of the photoreceptor-RPE-Bruch's membrane-choriocapillaris complex. Family and twin studies have shown that the susceptibility for this disease is genetically influenced. The heritability has been estimated to be up to 71%. Linkage and association studies have identified several chromosomal regions that are likely to contain ...