Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

URN to cite this document:: urn:nbn:de:bvb:355-epub-358613
DOI to cite this document:: 10.5283/epub.35861

Couch, F. J. ; Wang, X. ; McGuffog, L. ; Lee, A. ; Olswold, C. ; Kuchenbaecker, K. B. ; Soucy, P. ; Weber, Bernhard H. F.

; et, al.

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Date of publication of this fulltext: 07 Jul 2017 11:47

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Abstract

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer ...