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PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas

Wappenschmidt, B, Wardelmann, E, Gehrig, A, Schondorf, T, Maass, N, Bonatz, G, Gassel, A M, Pietsch, T, Mallmann, P, Weber, Bernhard H. F. and Schmutzler, R K (2004) PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas. Human Pathology 35 (10), pp. 1260-1265.

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Abstract

PTEN and β-catenin mutations constitute the predominant genetic alterations in endometrioid carcinomas of the endometrium. PTEN encodes a dual-specificity phosphatase with lipid phosphatase and protein tyrosine phosphatase activities that regulate both apoptosis and interactions with the extracellular matrix. Recent studies have associated PTEN mutations with tumorigenesis of prostate carcinoma ...

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Item type:Article
Date:2004
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1016/j.humpath.2004.06.007DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35916
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